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TL1 Training Program

The TRANSFORM TL1 Training Programs are intended to provide scholars with additional research training to prepare for a research career that can contribute in some meaningful way to understanding risk of disease, improving diagnosis and prevention, and tailoring treatment based on an individual’s variation in genes, environment, and/or lifestyle.

With funding from the NIH CTSA award, the Irving Institute for Clinical and Translational Research seeks to promote high-quality research, enhance the integration of clinical and translational science, and deliver advancements more quickly to the patient community. An integral part of this effort are the TL1 Training Programs.

We offer the following programs:

Here are some examples of potential research topics:

  • Ecological momentary assessment of stress to identify personalized triggers for atrial fibrillation
  • Using genetic profile of breast cancer tissue to target therapy
  • N-of-1 trial to assess individualized treatment strategy for hypertension
  • Apply machine learning to EHR data to predict individualized risk of hospital readmissions
  • Integrating data from wearable devices with neighborhood walkability index to predict cardiovascular risk

For more topic examples, see our Current and Past Trainees.

If you have any questions regarding the TL1 program, please send an e-mail to Sophia Li Ferry.

 

FUNDING OPPORTUNITY FOR DOCTORAL STUDENTS
The TL1 program provides doctoral students with two years* of research training, which runs simultaneously with students’ ongoing doctoral training. The program allows doctoral students to gain knowledge and skill-sets that may be outside of their primary academic or clinical discipline. The interdisciplinary education gained as a TRANSFORM TL1 trainee will serve as an invaluable asset in conducting future research and collaborating with scientists and investigators from other clinical and academic fields of knowledge. Participation in this program will not necessitate extending an individual’s doctoral training program.

Eligibility: Doctoral Students entering their third year or beyond are preferred.

Timeline
Priority Deadline:
 February 1, 2018
Rolling Admission thereafter
Award Start Date: July 1, 2018

TL1 Doctoral Information

TL1 Doctoral Application

TL1 Doctoral Recommendation Form

*Initially awarded for 1 year and renewed for a second year with satisfactory progress.

If you have any questions regarding the TL1 program, please send an e-mail to Sophia Li Ferry.

 

FUNDING OPPORTUNITY FOR POSTDOCTORAL APPOINTEES
The TL1 program provides postdoctoral fellows with two years* of support to participate in an integrated didactic and mentored training program. Postdoctoral candidates are required to dedicate full-time to research and training related to precision medicine. The CTSA support includes funds for stipend (stipend level is determined by the number of full years of relevant postdoctoral experience when the award is issued), travel expenses, training related expenses such as supplies and health insurance, and tuition and fees in accordance with NIH policy.

Timeline
Priority Deadline: March 1, 2017
Rolling Admission thereafter
Award Start Date: Immediate

Postdoctoral TL1 Information

Postdoctoral TL1 Application

Postdoctoral TL1 Recommendation Form

Timeline
Priority Deadline: March 1, 2018
Rolling Admission thereafter
Award Start Date: Immediate

Postdoctoral TL1 Information

Postdoctoral TL1 Application

Postdoctoral TL1 Recommendation Form

*Initially awarded for 1 year and renewed for a second year with satisfactory progress.

If you have any questions regarding the TL1 program, please send an e-mail to Sophia Li Ferry.

 

FUNDING OPPORTUNITY FOR PRE-DOCTORAL STUDENTS
The TL1 Summer Training Program provides doctoral students with a summer stipend over the 12 week program. Students are expected to attend didactic training as well as participate in experiential learning. The program allows pre-doctoral students to gain knowledge and skill-sets that may be outside of their primary academic or clinical discipline. The interdisciplinary education gained as a TRANSFORM TL1 trainee will serve as an invaluable asset in conducting future research and collaborating with scientists and investigators from other clinical and academic fields of knowledge.

Eligibility: Doctoral students in between their first and second year of coursework are preferred. Open to US Citizens and Permanent Residents

Applications due: February 6, 2018

If you have any questions regarding the TL1 program, please send an e-mail to Sophia Li Ferry.

 

TRANSFORM TL1 Program Director

  Wendy K. Chung, MD, PhD
Associate Professor of Pediatrics (in Medicine), Columbia University Medical Center
     
Ye, Siqin   Siqin Ye, MD
Assistant Professor of Medicine, Columbia University Medical Center

 

Precision Medicine Research Education Program Participants

Doctoral students:

Nicole Blumenfeld
Next-generation sequencing on a chip

Anne Bozack
Epigenetic effects of Arsenic Exposure and Effect Modification by Nutritional Status

Eric Bryant
A Rapid and Cost-Efficient Strategy to Develop a Precision Therapy for Cancers Overexpressing HLTF

Sarah Dugger
Hitting the Bullseye: Identifying Targeted Treatments for Hnrnpu-related Epilepsy using in vivo and in vitro disease models

Alexander Hsieh
Investigating the functional consequence of noncoding variants in the context of human tissue and disease

Dantong Huang
Development of Patient-Specific Hepatocyte Spheroids for Disease Modeling and Drug Screening

Brahma Kumar
Mechanisms of memory T cell retention to the lung in Humans

William Raab
RNF43 mutations as a diagnostic Biomarker of CDX2 Negative Colon Carcinomas and a Predictive Biomarker of Colon Cancer response to anti-EGFR monoclonal antibodies

 

Postdoctoral Fellows:

Robyn Gartrell
Defining Critical features of the Immune microenvironment in neuroblastoma

Kimberly Komatsubara, MD
Personalized Medicine in the Adult Experimental Therapeutics Cancer Clinic at Columbia University Medical Center

Allison Norful, MSN, MPhil, RN, ANP-BC
The Development and Psychometric Testing of the Precision Co-management Index: A Pilot Project to Investigate the Impact of Shared Decision Making on Chronic Disease Management and Patient Center Outcomes

Neha Raghavan, PhD
Identification of novel Alzheimer’s Disease associated genes in a Multi-ethnic Cohort

Jeremy Worley,
Identification of Master Regulators in Breast Cancer tumor Subpopulations using a novel single-cell Analysis Pipeline, and the Prediction of Optimal Therapy

 

Precision Medicine Graduates of the Program:

Mary Boland
Systems-Level Approach to Understand the Effects of Prenatal/Perinatal Seasonal Exposures

Jacqueline Gunther
Using Diffuse Optical Tomography to Monitor Tumor Progression During Neoadjuvant Chemotherapy

Victor Gamarnik
Multimodal assessment of left ventricular dysfunction using ultrasound and MRI-based 3D strain estimation

Matko Kalac
Development of a novel, anti-CD70 based platform for the treatment of peripheral T-cell lymphomas

Annie Lee
Methods for age-specific penetrance estimate of LRRK2 mutations on the risk of Parkinson’s disease incorporating personalized characteristics

Purnema Madahar
Genomic characterization and clinical phenotypes of patients with idiopathic pulmonary fibrosis

Timothy Olsen                            
Microfluidic Selection of Aptamers for Therapeutic Applications

Sindhuri Prakash
A novel gene for IgA nephropathy through next gen sequencing

Sakellarios Zairis
Genomic characterization of NASH-related hepatocellular carcinoma

2017 Summer Trainees

Margaret Bogardus
Evaluating Immune Biomarkers in Melanoma using Multiplex Immunohistochemistry

Christopher DeAllie
Does Higher Severity Cobb angle in Cerebral Palsy patients increase need for Respiratory Assistive Aids?

Rachel Field
Delivery Mechanisms of Replacement Dopaminergic Cells for Parkinson’s Disease Patients

Linda Wang
Identifying Novel Breast Cancer Genes

Graduates of the Program

Dana Alessi, Cellular, Molecular and Biophysical Studies
Integrated Program in Cellular, Molecular and Biomedical Studies

Hilary Armstrong, Epidemiology
Analyses from the Multi-Ethnic Study of Atherosclerosis (MESA)

Maria Avrutsky, Integrated CMBS
Pharmacological modulation of tau in embryonic stem cell-derived neurons

Sarah Canetta, Neurobiology and Behavior
Type III Nrg1-erbB Signaling in Nociception

Julie Choe, Sociomedical Sciences
Bridging the technology divide - Translational science and technological innovation in medicine

Jennifer Crowe, Pathobiology and Molecular Medicine
Non-Catalytic Functions of DNA-PK in DNA repair and tumorgenesis

Annina DeLeo, Cellular, Molecular, and Biomedical Studies
MicroRNA Regulation of the switch from Qiuescent to Activated cell state in Adult Neural Stem Cells

Zhi-De Deng, Electrical Engineering
Field Shaping and Coil Design for Transcranial Magnetic Stimulation (TMS)

Roxanne Dutia, Institute for Human Nutrition
Hypothalamic Melancontin Regulation of Energy Balance and Metabolism

Allana Forde, Epidemiology
Impact of Social Stressors on Chronic Disease Risk in Black Ethnic Groups

Ambar Grijalva, Nutritional and Metabolic Biology
Role of autophagy in regulating lipid metabolism in adipose tissue macrophages

Erin Harelton, Pharmacology
TASK-1 in Arrhythmogenesis Downstream of PAF Signaling

Millie Hepburn-Smith, Nursing
Reduction of Stroke Risk in Minority Women

Ryo Higuchi, Nutritional and Metabolic Biology
The Role of the Actin Cytoskeleton on Segegragtion of Aging Determinants and Lifespan in Budding Yeast

Allan Just, Environmental Health Sciences
A Molecular Epidemiologic Study of Endocrine Disruptors and Pediatric Asthma

Linda Kahn, Epidemiology
Allostatic load and semen quality

Nowai Keleekai, Nursing
Study of Mental Health Services of an HIV-positive Incarcerated Population

Kristen Klemenhagen, Neurobiology & Behavior
Developmental Role of the 5-HT1A Receptor in Establishing Adult Anxiety Behavior

Jorge Luna, Epidemiology
Acute and chronic infectious predictors of stroke.

Ann Madsen, Epidemiology
Common Cause Model for Genetic Epidemiology and Risk-Factor Epidemiology: Laying the Foundation for Integration

David Malito, Neurobiology
Calcium Channel Mutations in Heart Arrythmias and Autism

Russell McBride, Epidemiology
Genetic Similarities in DNA Repair Polymorphisms between BRCA2 and HNPCC syndromic cancer families

Arthur Mikhno, Biomedical Engineering
Non-Invasive and cost effective quantification of Positron Emission Tomography data

Megan Niedzwiecki, Environmental Health Sciences
Title: TBD (Molecular Epidemiology)

Stan Okrasinski, Biomedical Engineering
In vivo clinical validation of myocardial elastography

James Papizan, Nutrition and Metabolic Biology
Structure-function analysis of the essential islet regulatory factor, Nkx2.2

Kristin Politi, Pathobiology & Molecular Medicine
Molecular mechanisms of motor neuron death in ALS

Catherine Richards, Epidemiology
Hospital-level Predictors of Immediate Breast Reconstruction

Kelly Ruggles, Nutrition and Metabolic Biology
Cellular fatty acid toxicity extrapolating yeast

Alex Smolak, School of Social Work
Culturally Congruent HIV Risk Reduction with Male Muslim Migrant Workers in Kazakhstan

Meghan Work, Epidemiology
Breast Cancer Risk Factors and Intermediate Markers and Associations with Tumor Characteristics

Hideaki Yano, Pharmacology
Understanding Mechanism of Dopamine Mediated HIV-Entry in NeuroAIDS

Gary That Vi Yu, Biostatistics
Evaluating and predicting clinical effectiveness of risk factors in CHD

 

 

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