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The Biomarkers Core Laboratory develops, validates and executes biochemical assays in support of any pre-clinical, translational and clinical research. The laboratory holds a clinical laboratory permit from NY State Department of Health (PFI 8006, CLIA: 33D0994879) and for specific projects, such as those that are part of drug development, the laboratory can adhere to FDA’s Good Laboratory Practice requirements.
The laboratory is constantly developing and validating new assays. For a list of the currently more than 200 validated assays and prices, please use the following links:
622 West 168 Street (PH-10-105)
Floor 10, Room 105
Phone: (212) 305-9287
Fax: (212) 305-3213
The 2,000 square-foot laboratory is located on the 10th floor of the Presbyterian Hospital building, adjacent to the outpatient and inpatient clinical research units of the Irving Institute. The lab runs a wide range of assays in biological fluids as well as tissue and cell homogenates, and is continuously developing new assays. Using the high-end mass spectrometers, Pharmacokinetics and Metabolomics sections have been set up within the lab, while the many manual and automated (immuno-)chemistry equipment is used to support campus-wide translational and clinical hormone, chemistry and biomarkers research. In addition, the lab has been serving as a Bio-repository to Columbia University Medical Center investigators for more than three decades.The laboratory is sufficiently staffed with several full-time research scientists and well-equipped with state-of-the-art instruments for manual and automated (immuno-) chemistry, and mass spectrometry assays. Specific equipment includes:
- Six (6) LC-MS/MS (Liquid Chromatography tandem Mass Spectrometry) instruments
- Two (2) GC-MS (Gas Chromatography Mass Spectrometry) instruments
- One (1) gamma and one (1) beta-counter for RIAs (RadioImmunoAssays)
- Three (3) plate readers for ELISAs (Enzyme Linked Immunosorbent assays)
- One (1) Luminex instrument (multiplex analyzer)
- Five (5) (immuno-)chemistry-analyzers
The Biomarkers Core Laboratory is the largest Mass Spectrometry facility at Columbia University Medical Center. The mass spectrometers are predominantly used for Targeted Metabolomics and Pharmacokinetics.
GC-MS and LC-MS/MS based Targeted Metabolomics panels include: Acyl Carnitines, Amino Acids, Bile Acids, Biogenic Amines, Carotinoids, Ceramides, Endocannabinoids, Fatty Acyl CoAs, Free Fatty Acids, Organic Acids, Oxysteroles, Phospholipids, Retonoids, Sphingolipids, Steroids, TCA-intermediates, Vitamin D metabolites, Wax+ethyl esters.
The laboratory also works closely with other laboratories such as the Department of Pathology and Cell Biology’s Center for Advanced Laboratory Medicine (CALM), the Biomarkers Laboratory and the Proteomics Facility at the Herbert Irving Comprehensive Cancer Center, the Hormone and Metabolite Core of the Diabetes and Endocrinology Research Center and the Organic Chemistry Collaborative Center of Medicine’s Division of Experimental Therapeutics.
For additional information please send an email to the Laboratory Director, Serge Cremers, PharmD, PhD, (firstname.lastname@example.org), contact the laboratory at 212-305-9287/9306, or submit a service request.
Tiffany Thomas, PhD, Assistant Professor of Pathology & Cell Biology
Hongfeng Jiang, MD, PhD, Associate Research Scientist
Zhengxiang Zhu, PhD, Associate Research Scientist
Alex Rai, PhD, Associate Professor of Pathology & Cell Biology
Steven Spitalnik, MD, Professor of Pathology & Cell Biology
Henry Ginsberg, MD, Irving Professor of Medicine