Single Cell Analysis Core

This service is provided in partnership with Columbia Genome Center and the Biomedical Informatics Resource.

Overview 

In partnership with Systems Biology, the Cancer Center, and the Institute for Genomic Medicine, the Irving Institute for Clinical and Translational Research created a  Single Cell Analysis Core to provide high-quality single-cell RNA sequencing (scRNA-seq) services.  

Custom analytics have proven indispensable for preparing manuscripts and grant applications (62 grant submitted since 2018, including successful Human Cell Atlas grant from the Chan Zuckerberg Initiative). In 2019, the Core conducted >700 scRNA-seq experiments for >75 laboratories in 18 departments and was on track (before COVID-19 pandemic) to double use and users in 2020. Core services help users get the most out of their scRNA-seq data without the daunting task of staying current on the rapidly evolving computational landscape in this field. The Core is essential to CU’s efforts to comprehensively profile the healthy and aging immune system in human tissues like for the Human Cell Atlas, an invaluable reference for immune dysfunction in disease. With Irving Institute support, the Core is developing computational infrastructure to support complex disease multi-omics applications, and consortium efforts. It is also implementing an end-to-end pipeline for scRNA-seq profiling hundreds of disease tissues per year to facilitate analysis of clinical trial specimens and to predict drug response. 

Eligibility 

The Single Cell Analysis Core services are available to all researchers Columbia University Irving Medical Center and other academic institutions. 

Cost 

Current prices are for Columbia users, are subsidized by institutional support, and subject to change. External users are welcome but should request a quote. 

Please find a full breakdown of pricing for Single Cell Analysis Core services here.

Cite it, Submit it, Share it! 

If your research has benefited from one or more Irving Institute resources, please remember to: 

• Cite our CTSA grant, UL1 TR001873, in any relevant publications, abstracts, chapters, and/or posters. 
• Submit your publications to PubMed Central (PMC) for compliance with the NIH Public Access Policy. 
• Share your research updates with us by sending an email to: irving_institute@cumc.columbia.edu