Precision Medicine Pilot Awardees

Targeting S100A9 using RA antagonists and nano ligases to treat CNS metastasis in lung cancer

• Swarnali Acharyya, PhD, Institute of Cancer Genetics (Principal Investigator)
• Henry Colecraft, PhD, Institute of Cancer Genetics (Co-Principal Investigator)
• Cathy Shu, MD, Med Hematology & Onc
• Jeff Bruce, MD, Neurological Surgery
• Guy McKhann, MD, Neurological Surgery
• Peter Canoll, MD, PhD, Pathology & Cell Biology

The Genetic Basis of Small for Gestational Age Preterm Birth

• Thomas Hays, MD, PhD, Pediatrics (Principal Investigator)
• Joshua Motelow, MD, PhD, Pediatrics
• Caitlin Baptiste, MD, Obstetrics and Gynecology

The impact of sleep fragmentation on memory dysfunctions in neuropsychiatric disorders

• Yueqing Peng, PhD, Institute of Genomic Medicine (Principal Investigator)
• Gergely Turi, PhD, New York State Psychiatric Institute (Co-Principal Investigator)

Metallomics MISSION: A comprehensive assessment of Metals, ISotopes and SpeciatioN as disease biomarkers and therapeutic targets

• Kathrin Schilling, PhD, Environmental Health Sciences (Principal Investigator)
• Ronald Glabonjat, PhD, Environmental Health Sciences (Co-Principal Investigator)
• Ana-Navas Acien, MD, PhD, Environmental Health Sciences (Co-Principal Investigator)
• Alex N Halliday, PhD, Columbia Climate School (Co-Principal Investigator)
• Hiroo Takayama, MD, Surgery (Co-Principal Investigator)
• Gervasio A Lamas, MD, Division of Cardiology at Mount Sinai Medical Center, Columbia University (Co-Principal Investigator)

Impaired cellular energetics and lipid metabolism in human iPSC-derived Cardiomyocytes carrying cardiomyopathy-causing mutations in genes encoding nuclear envelope proteins

• Ji-Yeon Shin, PhD, Medicine (Principal Investigator)
• Barry M. Fine, MD, PhD, Medicine
• Hanrui Zhang, PhD, Medicine

The Immunopathology of Donor-Derived APOL1 Nephropathy 

• Ibrahim Batal, MD, Pathology and Cell Biology (Principal Investigator) 
• Kevin Gardner, MD, PhD, Pathology and Cell Biology 
• Barry Freedman, MD, Wake Forest School of Medicine 
• Iuliana Ionita-Laza, PhD, Biostatistics 

Optimization of Small Molecules that Restore Enzyme Activity to R152H GPX4 

• Brent Stockwell, PhD, Biological Sciences (Principal Investigator) 
• Farhad Forouhar, PhD, Herbert Irving Comprehensive Cancer Center 
• Mohammed N. AlQuraishi, PhD, Systems Biology 

Study of Sleep as an Essential Factor in Aging: Analysis of Biological Biomarkers as Mediators in the Development of Cardiovascular Diseases 

• Marie-Pierre St-Onge, PhD, Medicine/Nutritional Medicine (Principal Investigator) 
• Lawrence Honig, MD, PhD, Neurology 
• Rocio Barragan, PhD, University of Valencia 
• Christian Dye, PhD, Environmental Health Sciences 
• Bin Cheng, PhD, Biostatistics 

Towards Precision Psychiatry: An In Vitro Model of Schizophrenia-associated Network Pathophysiology 

• Raju Tomer, PhD, Biological Sciences (Principal Investigator) 
• Joseph Gogos, MD, PhD, Physiology and Cellular Biophysics, Neuroscience and Psychiatry 
• Sander Markx, MD, PhD, Psychiatry 

Central Memory T cells in the Human Colorectal Cancer Immune Microenvironment 

• Kelley Yan, MD, PhD, Medicine and Genetics and Development (Principal Investigator) 
• Arnold Han, MD, PhD, Medicine and Microbiology and Immunology (Co-Principal Investigator) 

Retinal Imaging and Deep Learning to Identify Maternal Risk & Reduce Racial Disparities

• Srilaxmi Bearelly, MD, Ophthalmology (Principal Investigator)
• Ronald Wapner, MD, Obstetrics and Gynecology
• Andrew Laine, DSc, Biomedical Engineering and Radiology

Patient-Derived Organoids to Model and Manipulate Tumor Regulatory Dependencies In Esophageal Adenocarcinoma

• Brian Henick, MD, Medicine/Hematology and Oncology (Principal Investigator)
• Andrea Califano, Dr, Systems Biology
• Chao Lu, PhD, Genetics and Development
• Hiroshi Nakagawa, MD, Medicine/Digestive and Liver Diseases

Direct Visualization of Malaria Parasite Invasion Using Cryoelectron Tomography

• Chi-Min Ho, PhD, Microbiology and Immunology (Principal Investigator)
• David Cobb, PhD, Microbiology and Immunology

Develop New Computational Methods to Predict Functional Impact of Missense Variants Based on Protein Structure Using Machine Learning

• Yufeng Shen, PhD, Systems Biology and Biomedical Informatics (Principal Investigator)
• Mohammed AlQuraishi, PhD, Systems Biology

A Special Ribosome in the Heart: Understanding how Mutations in Ribosomal Protein RPL3L Cause Neonatal Dilated Cardiomyopathy by Using Patient-derived iPSCs and Genetically Engineered Mice

• Xuebing Wu, PhD, Systems Biology and Medicine/Cardiology (Principal Investigator)
• Steven Marx, MD, Medicine/Cardiology and Pharmacology
• Teresa Lee, MD, Pediatrics/Cardiology
• Mythily Ganapathi, PhD, Pathology and Cell Biology

Biological and Therapeutic Relevance of Exosomes in Uveal Melanoma

• Richard Carvajal, MD (Principal Investigator)
• Alex Rai, MD
• Grazia Ambrosini, PhD

Mechanistic Investigation of the Vaginal Microbiome in Different Manifestations of Spontaneous Preterm Birth

• Tal Korem, PhD (Principal Investigator)
• Anne-Catrin Uhleman, MD, PhD
• George Gallos, MD
• Joy-Sarah Vink, MD

A microRNA Approach to Identify Renal Osteodystrophy Sub-Type

• Thomas Nickolas, MD, MS (Principal Investigator)
• Stavroula Kousteni, PhD
• Krzysztof Kiryluk, MD, MS

Deciphering Monogenic and Polygenic Etiologies of a Longitudinal Multi-Ethnic Hidradenitis Suppurativa Cohort

• Lynn Petukhova, PhD (Principal Investigator)
• Suzanne Leal, PhD

Unbiased Screen of Proximal and Distal Splicing Regulatory Elements Towards Drug Discovery

• Chaolin Zhang, PhD (Principal Investigator)
• Samuel Sternberg, PhD

Identification of Precision Diagnostic and Therapeutic Targets for Advanced Prostate Cancer Patients Based on Mechanistic RNA Landscape

• Howard Lieberman, PhD, Radiation Oncology (Principal Investigator)
• Israel Deutsch, MD, Radiation Oncology
• Richard Friedman, PhD, Biomedical Informatics
• Sven Wenske, MD, Urology

Application of Multi-Omics Profiling to Predict Adverse Left Ventricular Remodeling and Cardivascular Events in Hypertrophic Cardiomyopathy

• Yuichi Shimada, MD, Medicine/Cardiology (Principal Investigator)
• Matthew Maurer, MD, Medicine/Cardiology
• Rajesh Soni, PhD, Medicine/Hematology and Oncology
• Renu Nandakumar, PhD, Medicine/General Medicine
• Kohei Hasegawa, MD, Medicine/Emergency Medicine

TBX3 as a Novel Regulator of POMC for Therapeutic Targeting 

• Vidhu Thaker, MD, Pediatrics/Molecular Genetics (Principal Investigator)
• Claudia Doege, MD, Pathology and Cell Biology 

Future Cardiovascular and Cerebrovascular Health Among Women with Severe Preeclampsia During Pregnancy and Delivery

• Kristen Cleary, MD, Obstetrics/Gyn MFM (Principal Investigator)
• Eliza Miller, MD, Medicine/Neurology
• Natalie Bello, MD, MPH, Medicine/Cardiology
• Ruth Landau, MD, Anesthesiology

Personalized Investigation of Disease Mechanisms and Prediction of Medication Responsiveness in Women with Pregnancy and Lactosis-Associated Osteoporosis

• Adi Cohen, MD, MHS, Medicine/Endocrinology (Principal Investigator)
• Stavroula Kousteni, PhD, Physiology and Cellular Biophysics
• Elizabeth Shane, MD, Medicine/Endocrinology
• Thomas Nickolas, MD, MS, Medicine/Nephrology

Understanding the Role of the Human Microbiome in Graves' Disease with and without Orbitopathy

• Lora Glass, MD, Ophthalmology (Co-Principal Investigator)
• Bryan Winn, MD, Ophthalmology (Co-Principal Investigator)
• Anne-Catrin Uhlemann, MD, PhD, Medicine/Infectious Diseases
• Stephen Tsang, MD, PhD, Ophthalmology
• Salila Kurra, MD, Medicine/Endocrinology
• Robert McConnell, MD, Medicine/Endocrinology

Towards a Molecular-Based Precision Medicine

• Rosemary Sampogna, MD, Medicine/Nephrology (Principal Investigator)
• Barry Honig, PhD, Systems Biology
• Lawrence Shapiro, PhD, Biochemistry and Molecular Biophysics

Implementing a Health Screening App to Match People with Lower Limb Loss at High Risk for Low Function to Personalized Physiotherapy and Injury Prevention Education

• Kevin Wong, PhD, Rehab & Regenerative Med PT (Principal Investigator)
• Gregory Youdan, MA, Teacher's College
• Stanford Chihuri, MS, Anesthesiology 

Definition of Acute Kidney Injury at Single Cell Resolution

• Jonathan Barasch, MD, PhD, Medicine: Nephrology (Principal Investigator)
• Peter Sims, PhD, Systems Biology
• Krzysztof Kiryluk, MD, Medicine: Nephrology
• Christopher Anderson, MD, Urology
• Pablo Gonzalez-Camara, PhD, Systems Biology
• Raul Rabadan, PhD, Systems Biology

Modeling and Prediction of Primary Graft Dysfunction After Heart Transplant

• Barry Fine, MD, PhD, Medicine: Cardiology (Principal Investigator)
• Gordana Vunjak-Novakovic, PhD, Biomedical Engineering
• Emily Chen, PhD, Pharmacology
• Emmanuel Zorn, PhD, Medicine: Cardiology
• Paolo Colombo, MD, Medicine: Cardiology
• Nicholas Tatonetti, PhD, Biomedical Informatics

Precision T-cell Receptor-based Cancer Therapies

• Arnold Han, MD, PhD, Medicine: Digestive and Liver Diseases (Principal Investigator)
• Yufeng Shen, PhD, Biomedical Informatics
• Kelley Yan, MD, PhD, Medicine: Digestive and Liver Diseases
• Paul Oberstein, MD, Hematology and Oncology
• Emmanuel Zorn, PhD, Medicine: Cardiology
• Sacher Adrian, MD, Hematology and Oncology

Patient-specific Computational Models to Guide Atrial Fibrillation Therapy

• Vivek Iyer, MD, Medicine: Cardiology (Principal Investigator)
• Hasan Garan, MD, Medicine: Cardiology
• Angelo Biviano, MD, Medicine: Cardiology

A TCR Sequencing Approach to Understanding Graft Dysfunction Following Transplantation for Autoimmune Liver Disease

• Mercedes Martinez, MD, Pediatrics: Gastroenterology, Hepatology and Nutrition (Principal Investigator)
• Megan Sykes, MD, Hematology and Oncology
• Elizabeth Verna, MD, Medicine: Digestive and Liver Diseases

Precision Delivery of c-Myc-Silencing Therapy by Identifying Genes Sensitive to Dual Inhibition of PI3Kδ and CK1ε

• Changchun Deng, MD, PhD, Medicine (Principal Investigator)
• Peter Sims, PhD, Systems Biology
• Donald Landry, MD, PhD, Medicine
• Karthik Ganapathi, PhD, Pathology and Cell Biology

Development of a Personalized Approach to the Evaluation and Treatment of Acromegaly: Integration of Genomic, Histopathologic and Radiographic Data With a Large, Existing Prospective Clinical Outcomes Dataset

• Pamela Freda, MD, Medicine (Principal Investigator)
• Peter Canoll, MD, PhD, Pathology and Cell Biology
• Jeffrey Bruce, MD, Neurosurgery
• Yufeng Shen, PhD, Biomedical Informatics
• Zhezhen Jin, PhD, Biostatistics
• Alexander Khandji, MD, Radiology

Precision Targeting of Pancreatic Cancer Regulatory Networks

• Kenneth Olive, PhD, Medicine (Principal Investigator)
• Andrea Califano, PhD, Systems Biology

A Functional Modeling Framework to Identify Actionable Alleles From Clinical Exome Sequencing

• Simone Sanna-Cherchi, MD, Medicine (Principal Investigator)
• Iuliana Ionite-Laza, PhD, Biostatistics
• Barry Honig, PhD, MS, Biochemistry and Molecular Biophysics

A Genetic Approach Toward Individualizing the Assessment of Osteoporosis

• Marcella Walker, MD, MS, Medicine (Principal Investigator)
• David Goldstein, PhD, Genetics and Development
• Edward Guo, PhD, MS, Biomedical Engineering
• Xiaolin Zhu, MB, Institute for Genomic Medicine

Model Enrichment in Reinforcement Learning for Optimal Personalized and Patient Centered Cancer Treatments

• Ying Kuen K. Cheung, PhD, Biostatistics (Principal Investigator)
• Joseph Jurcic, MD, Medicine
• Shing Lee, PhD, Biostatistics
• Min Qian, PhD, Biostatistics
• Gary Schwartz, MD, Medicine

Personalized Pharmacology for Neonatal Cardiac Patients at Risk for Arterial Thrombotic Events

• Thomas Diacovo, MD, Pediatrics (Principal Investigator)
• Samuel Sia, PhD, Biomedical Engineering

Donor-Recipient Genomic Incompatibilities in Solid Organ Transplant

• Krzysztof Kiryluk, MD, MS, Medicine (Principal Investigator)
• David J. Cohen, MD, Medicine
• Vivette D. D’Agati, MD, Pathology and Cell Biology
• Jean C. Emond, MD, Surgery
• Susan Restaino, MD, Medicine
• Elizabeth Verna, MD, Medicine
• Chunhua Weng, PhD, Bioinformatics
• Emmanuel Zorn, PhD, Medicine

A New Biomarker of Kidney Transplant Outcomes: Tracking the Fate of Donor-Reactive T Cells in the Blood and Urine

• Heath Morris, MD, Medicine (Principal Investigator)
• Yufeng Shen, PhD, Biomedical Informatics
• Megan Sykes, MD, Medicine

Clinical and Psychosocial Utility of Whole Exome Sequencing in Pediatric Epilepsy

• Ruth Ottman, PhD, Epidemiology (Principal Investigator)
• Cigdem Inan Akman, MD, Neurology
• Hyunmi Choi, MD, MS, Neurology
• Arthur Jeff Goldsmith, PhD, Biostatistics
• Dale C. Hesdorffer, PhD, Epidemiology
• Karolynn Siegel, PhD, Social Work
• Annapurna Poduri, MD, PhD, Harvard Medical School

Personalized Aptamers for MRD in Multiple Myeloma

• Tilla Worgall, MD, PhD, Pathology and Cell Biology (Principal Investigator)
• Qiao Lin, PhD, Mechanical Engineering
• Milan Stojanovic, PhD, Medicine