Irving Multi-PI Planning Grant Awardees

Convection-enhanced delivery for brain tumors

• Jeffrey Bruce, MD, Neurological Surgery (Principal Investigator)
• Peter Canoll, MD, PhD, Pathology and Cell Biology  (Co-Principal Investigator)
• Andrea Califano, Dr, Systems Biology
• Andrew Lassman, MD, Neurology – Neuro-Oncology
• Raul Rabadan, PhD, Systems Biology
• Peter Sims, PhD, Systems Biology

Translational mechanistic biomarkers for precision intervention and etiological investigation in first episode schizophrenia

• Daniel Javitt, MD, PhD, Psychiatry - Experimental Therapeutics (Principal Investigator)
• Guillermo Horga, MD, PhD, Psychiatry - Translational Imaging
• Jia Guo, PhD, Psychiatry - Experimental Therapeutics
• Joshua Kantrowitz, MD, Psychiatry - Experimental Therapeutics
• Lawrence Kegeles, MD, Psychiatry - Translational Imaging
• Frank Provenzano, PhD, Neurology - Aging and Dementia

Understanding and targeting epigenetic and metabolic alternations in HNSCC pathobiology

• Hiroshi Nakagawa, MD, PhD, Medicine - Digestive and Liver Diseases (Principal Investigator)
• Chao Lu, PhD, Genetics and Development (Co-Principal Investigator)
• J. Allen Diehl, PhD, Biochemistry, Case Western Reserve University
• Quintin Pan, PhD, Otolaryngology, Case Western Reserve University
• Theodoros Teknos, MD, University Hospitals Seidman Cancer Center, University Hospitals Cleveland Medical Center and Otolaryngology, Case Western Reserve University

Prospective Genetic Risk, Emergence, and Pre-Symptomatic Intervention for Autism Spectrum Disorder

• Wendy Chung, MD, PhD, Pediatrics - Clinical Genetics (Principal Investigator)
• Jeremy Veenstra-VanderWeele, MD, Psychiatry - Child and Adolescent (Co-Principal Investigator)

• Dima Amso, PhD, Psychology
• Paul Applebaum, MD, Psychiatry - Mental Health Service Research and Policy 
• Jennifer Bain, MD, PhD, Neurology – Child Neurology
• William Fifer, PhD, Psychiatry - Developmental Neuroscience 
• Sylvie Goldman, PhD, Neurology – Child Neurology
• Stephen Kanne, PhD, Weill Cornell Medical College
• So Hyun Kim, PhD, Weill Cornell Medical College
• Matthew Lebowitz, PhD, Psychiatry – Mental Health Service Research and Policy
• Rebecca Muhle, MD, PhD, Psychiatry – Child and Adolescent and Developmental Neuroscience
• Anna Penn, MD, PhD, Pediatrics - Neonatology
• Yufeng Shen, PhD, Systems Biology and Biomedical Informatics
• Kally Sparks, PhD, Psychiatry – Child and Adolescent
• Dennis Vitkup, PhD, Systems Biology and Biomedical Informatics
• Chaolin Zhang, PhD, Systems Biology and Biochemistry and Molecular Biophysics 

Epigenetic remodeling, emergency myelopoiesis and stromal cell signaling-induced stem cell reprograming in AML transformation

• Stavroula Kousteni, PhD, Physiology – Research (Principal Investigator)
• Emmanuel Passegue, PhD, Genetics and Development (Co-Principal Investigator)
• Adolfo Ferrando, MD, Pediatrics (Co-Principal Investigator)
• Jellert Gaublomme, PhD, Arts and Sciences - Biological Sciences
• Raul Rabadan, PhD, Biomedical Informatics

Center for Intergenerational Psychiatry

• Jonathan Posner, MD, Psychiatry - Child and Adolescent (Principal Investigator)
• Cristiane Duarte, PhD, MPH, Psychiatry - Child and Adolescent (Co-Principal Investigator)
• Christoph Anacker, PhD, Psychiatry – Systems Neuroscience
• Andrea Baccarelli, MD, PhD, MPH, Environmental Health Sciences
• Catherine Monk, PhD, Obstetrics and Gynecology – Research
• Myrna Weissman, PhD, MSW, Psychiatry and Epidemiology

Investigating cell-intrinsic and extrinsic interactions in prostate cancer at the single-cell level

• Michael Shen, PhD, Medicine - Hematology and Oncology (Principal Investigator)
• Cory Abate-Shen, PhD, Molecular Pharmacology and Therapeutics (Co-Principal Investigator)

Translating Rare Disease Discoveries into Improved Care via a Learning Health System

• Chunhua Weng, PhD, Biomedical Informatics (Principal Investigator)
• Paul Applebaum, MD, Psychiatry - Mental Health Service Research and Policy (Co-Principal Investigator)
• Wendy Chung, MD, PhD, Pediatrics - Clinical Genetics (Co-Principal Investigator)
• Cong Liu, PhD, Biomedical Informatics (Co-Principal Investigator)
• George Hripcsak, MD, Biomedical Informatics
• Rachel Lewis, MD, Pediatrics

Epigenetic Regulation of Endogenous Retroviral DNAs and Consequences for Tumor Immunotherapy

• Stephen Goff, PhD, Biochemistry and Molecular Biophysics (Principal Investigator)
• Songtao Jia, PhD, Arts and Sciences - Biological Sciences (Co-Principal Investigator)
• Zhiguo Zhang, PhD, Pediatrics - Molecular Genetics (Co-Principal Investigator)
• Chao Lu, PhD, Genetics and Development - Genetics and Development
• Jennifer Amengual, MD, Medicine - Experimental Therapeutics

Exposomics: harmonization of high-resolution mass spectrometry for detection of exogenous chemicals in clinical research         

• Gary Miller, PhD, Environment Health Science (Principal Investigator)

• Ali Gharavi, MD, Medicine - Nephrology (Co-Principal Investigator)
• Dean Jones, PhD, Medicine
• Douglas  Walker, PhD, Environmental Medicine and Public Health
• Konstantinos Lazaridis, MD, Medicine
• Krystal Pollitt, PhD, Epidemiology

Integrated Approaches to Detect and Treat Eosinophilic Esophagitis (EoE)             

• Jianwen Que, MD, PhD, Medicine - Digestive and Liver Diseases (Principal Investigator)

• Hiroshi Nakagawa, MD PhD, Medicine - Digestive and Liver Diseases (Co-Principal Investigator)
• Julian Abrams, MD, Medicine - Digestive and Liver Diseases (Co-Principal Investigator)
• Seema Aceves, MD, PhD, Medicine - Digestive and Liver Diseases (Co-Principal Investigator)
• Dominique Bailey, MD, Pediatrics - Gastroenterology

Understanding and targeting cell-cell crosstalk in NASH-associated liver fibrosis and liver cancer

• Robert Schwabe, MD, Medicine - Digestive and Liver Diseases (Principal Investigator)

• Ira Tabas, MD, PhD, Medicine - Molecular Medicine (Co-Principal Investigator)
• Utpal Pajvani, MD, PhD, Medicine - Endocrinology (Co-Principal Investigator)

The Precision Medicine Digestive Disease Research Center           

• Timothy  Wang , MD, Medicine - Digestive and Liver Diseases (Principal Investigator)

• Kara  Gross-Margolis, MD, Pediatrics (Co-Principal Investigator)
• Howard Worman, MD, Medicine - Digestive and Liver Diseases
• Jianwen Que, MD PhD, Medicine - Digestive and Liver Diseases
• Liza Pon, PhD, Pathology and Cell Biology

Collaborative Projects in Oral Dysplasia and Carcinoma  

• Angela Yoon, DDS, MPH, MAMSc, College of Dental Medicine - Oral Pathology (Principal Investigator)

• Elizabeth Philipone, DMD, College of Dental Medicine - Oral Pathology (Co-Principal Investigator)
• Hiroshi Nakagawa, MD, PhD, Medicine - Digestive and Liver Diseases (Co-Principal Investigator)

• Richard Carvajal, MD, Medicine - Hematology and Oncology (Co-Principal Investigator)
• Gloria Su, PhD, Pathology and Cell Biology - Pathology (Co-Principal Investigator)
• Fatemeh Momen-Heravi, DDS, PhD, MPH, MS, College of Dental Medicine - Periodontics (Co-Principal Investigator)