BERD Web Applications

Trial Design & Conduct Apps

Contact

Biostatistics Education
622 West 168th Street, 10th Floor
New York, NY 10032
United States

The trial and conduct apps allow users to upload a dataset and assign the next dose or determine the maximum tolerated dose. The apps contain descriptions of the required data as well as sample datasets.

  • CRM Conduct

    • Assign next dose and estimate MTD using CRM

    The Continual Reassessment Method (CRM) is a model-based design for phase I trials which aims to find the maximum tolerated dose of a new therapy.

    Dose-finding app icon

  • PRO-CRM Conduct

    • Assign next dose and estimate MTD using PRO-CRM

    Patient-Reported Outcomes Continual Reassessment Method (PRO-CRM) incorporates both clinician and patient perspective to estimate the maximum tolerated dose.

    PRO-CRM icon

  • TiTE-CRM Conduct

    • Assign next dose and estimate MTD using TiTE-CRM

    Time-to-Event Continual Reassessment Method (TiTE-CRM) accounts for the timing of late-onset toxicities and results in shorter trial duration.

    TiTE CRM app icon

 

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